Thymectomy in the neonatal rat
نویسندگان
چکیده
منابع مشابه
Effect of Neonatal Thymectomy on Hemopoietic Tissue in Mice
The influence of neonatal thymectomy on the behavior of hemopoietic stem cells of bone marrow and spleen was investigated by studying the colony-forming capacity (CFC) of these cells. Bone marrow cells (2 X 104) from neonatally thymectomized C3H mice, injected into lethally irradiated (850 R) recipients, showed a reduced CFC in relation to that of intact control donors. This decrease, which was...
متن کاملEffect of Neonatal Thymectomy on Hemopoietic Tissue in Mice
The influence of neonatal thymectomy on the behavior of hemopoietic stem cells of bone marrow and spleen was investigated by studying the colony-forming capacity (CFC) of these cells. Bone marrow cells (2 X 104) from neonatally thymectomized C3H mice, injected into lethally irradiated (850 R) recipients, showed a reduced CFC in relation to that of intact control donors. This decrease, which was...
متن کاملEffect of neonatal thymectomy on hemopoietic tissue in mice.
The influence of neonatal thymectomy on the behavior of hemopoietic stem cells of bone marrow and spleen was investigated by studying the colony-forming capacity (CFC) of these cells. Bone marrow cells (2 X 104) from neonatally thymectomized C3H mice, injected into lethally irradiated (850 R) recipients, showed a reduced CFC in relation to that of intact control donors. This decrease, which was...
متن کاملThree day neonatal thymectomy selectively depletes NK1.1+ T cells.
Neonatal thymectomy of mice 3 days after birth but not at birth leads to T cell-mediated, organ-specific, autoimmune disease in a strain-dependent manner. The mechanisms that lead to disease in this model remain unknown, but the answer may lie in a deficiency of thymus-dependent cells or factors. One candidate is the relatively rare population of NK1.1 + T cells (NKT cells). Conventional alphab...
متن کاملHuman neonatal thymectomy induces altered B‐cell responses and autoreactivity
An association between T-cell lymphopenia and autoimmunity has long been proposed, but it remains to be elucidated whether T-cell lymphopenia affects B-cell responses to autoantigens. Human neonatal thymectomy (Tx) results in a decrease in T-cell numbers and we used this model to study the development of autoreactivity. Two cohorts of neonatally thymectomized individuals were examined, a cohort...
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ژورنال
عنوان ژورنال: Laboratory Animals
سال: 1975
ISSN: 0023-6772,1758-1117
DOI: 10.1258/002367775780994664